Methods for the treatment or prophylaxis of thrombosis or embolism
AssigneeIPCA Laboratories Ltd.
InventorsAshok Kumar, Nellithanath Thankachen Byju
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Abstract
The present invention relates to a method of ameliorating the drawbacks of anti-platelet drug named clopidogrel. The method of the present invention comprises administration of an (S)oxo-clopidogrel or its derivative of the Formula IIA in its free or pharmaceutically acceptable salt form for alleviating the symptoms of thrombosis or embolism by inhibiting blood platelet aggregation. Compositions for use in such methods are also provided.
Claims30
A method for reducing or alleviating inter individual platelet response variability and metabolic loading in humans in the treatment or prophylaxis of thrombosis or embolisms observed following administration of clopidogrel comprising administering to a person in need thereof, a composition containing an effective amount of S-oxo-clopidogrel or a compound of Formula IIA
- or pharmaceutically acceptable salts thereof, wherein R is hydrogen or an acyl or alkyl substituted silyl group.
A method of treatment or prophylaxis of thrombosis or embolisms in a patient in need thereof comprising administering a composition a composition containing an effective amount of S-oxo-clopidogrel or a compound of Formula IIA
- or pharmaceutically acceptable salts thereof, wherein R is hydrogen or an acyl or alkyl substituted silyl group;
- wherein said administration avoids the side effects associated with the clopidogrel acid metabolite of Formula IV
A method of treatment or prophylaxis of thrombosis or embolisms in a clopidogrel non-responder- or poor-responder-patient in need of such treatment, comprising administering an effective amount of a composition containing S-oxo-clopidogrel or a compound of Formula IIA
- or pharmaceutically acceptable salts thereof, wherein R is hydrogen oran acyl or alkyl substituted silyl group.
A method of treating clopidogrel resistance in a patient in need of treatment or prophylaxis of thrombosis or embolisms, comprising administering an effective amount of a composition containing S-oxo-clopidogrel or a compound of Formula IIA
- or pharmaceutically acceptable salts thereof, wherein R is hydrogen or an acyl or alkyl substituted silyl group.
Dependencies are inferred from the claim text.