Isotopically enriched pyrimidin-5-yl acetic acid derivatives as CRTH2 antagonists
AssigneeActimis Pharmaceuticals, Inc.
InventorTai Wei Ly
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Abstract
Provided herein are 2H- and 13C-enriched compounds of formula (I) or (II); wherein R is as defined herein, and wherein at least one hydrogen atom, in certain embodiments, three or more hydrogen atoms, are deuterium atoms or at least one carbon atom is a carbon-13 atom. Also provided are pharmaceutical compositions and methods using the 2H- and 13C-enriched compounds, useful for treating CRTH2-related diseases or disorders such as, for example, asthma, allergic rhinitis, atopic dermatitis, allergic conjuvatitis, Churg-Strauss syndrome, sinusitis, basophilic leukemia, chronic urticaria or basophilic leukocytosis.
Claims12
An isotopically enriched compound of formula I:
- or pharmaceutically acceptable salt thereof,
- wherein
- R is hydrogen, C1-6 alkyl, C3-8 cycloalkyl optionally substituted by C1-6 alkyl, or phenyl optionally substituted with 1-4 substituents selected from halogen, C1-4 alkyl optionally substituted with mono-, di- or tri- halogen, and C1-4 alkoxy;
- and wherein
- one or more hydrogen atoms are replaced by a deuterium atom or
- one or more carbon atoms are replaced by a carbon-13 atom.
Dependencies are inferred from the claim text.