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US 8,541,398 B2Granted
Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs
AssigneeAntibe Therapeutics Inc.
InventorsJohn L. Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
Life of this patent
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Abstract
The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.
Claims18
A compound of the formula:
- A—Y—X (Formula I)
- wherein A is an NSAID radical, Y is selected from the group consisting of —C(O)O—, —C(O)NH—, —C(O)OC(O)—, —C(O)NHCH2C(O)—, or zero, and X is either
- or a salt thereof;
- whereby when Y is zero, the compound may be a salt of A and X.
1 more element
A compound of the formula:
- B—C(O)O—X (Formula II)
- where B—C(O)O— is derived from an NSAID having a free carboxyl group or a carboxy-substituted NSAID, and X is
- or a salt thereof.
Dependencies are inferred from the claim text.