Alkyne and alkene derivatives as sphingosine 1-phosphate-1 receptor modulators

A compound having Formula I, its enantiomers, diastereoisomers, or a pharmaceutically acceptable salt thereof,

• wherein:
• represents a double bond “—CR14═CR15—”;
• A is C6-10 aryl, heterocycle, C3-8 cycloakyl or C3-8 cycloalkenyl;
• B is C6-10 aryl, heterocycle, C3-8 cycloakyl or C3-8 cycloalkenyl;
• R1 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
• R2 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
• R3 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
• R4 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
• R5 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
• R6 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
• R7 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, C6-10 aryl, heterocycle, C3-8 cycloakyl, C3-8 cycloalkenyl, NR12R13 or hydroxyl;
• R8 is the same or independently halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
• L1 is O, S, NH or CH2;
• R9 is H or C1-6 alkyl;
• L2 is CHR14 or O;
• R10 is H, OPO3H2, carboxylic acid, hydroxyl, PO3H2, —S(O)2H, —P(O)MeOH or —P(O)(H)OH;
• R11 is H or C1-8 alkyl;
• a is 0, 1, 2 or 3;
• b is 0 or 1;
• R12 is H or C1-8 alkyl;
• R13 is H or C1-8 alkyl;
• R14 is H, hydroxyl or C1-8 alkyl;
• R15 is H or C1-8 alkyl;
• R16 is O, S, C(O) or CH2;
• and
• c is 0 or 1;
• with the proviso that the compound of Formula I is not of structure