US 8,541,394 B2Granted

Aminoglycoside antibiotics

AssigneesMeiji Seika Pharma Co., Ltd., Microbial Chemistry Research Foundation

InventorsYoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda

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Abstract

This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.

Claims5

Dependent claims

A method for inhibiting proliferation of methicillin-resistant Staphylococcus aureus, or for sterilizing methicillin-resistant Staphylococcus aureus;

comprising administering a compound represented by formula (Ia) or its pharmacologically acceptable salt, or their diastereomer mixture with respect to the carbon atom attached with * to an animal:
wherein
R5ax and R5eq, which are different from each other, represent a hydrogen atom or hydroxyl, and
R4″ax and R4″eq, which are different from each other, represent a hydrogen atom or hydroxyl,
n is an integer of 1 to 4, and
the steric configuration of carbon atom attached with * represents R or S.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/413,979Filed 7 Mar 2012 · division
Priority: JP 2006-1550622 Jun 2006
Published: US 2012/0165283 A128 Jun 2012
Granted: 24 Sep 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07H 15/234
With at least two saccharide radicals directly attached to the cyclohexane rings: attached to non-adjacent ring carbon atoms of the cyclohexane…
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
C07H 15/224
Cyclohexane rings substituted by at least two nitrogen atoms: with only one saccharide radical directly attached to the cyclohexyl radical, e.g.…
C07H
Sugars

Family

PCT/JP2007/061209Parent of this division · filed 1 Jun 2007
US 2012/0165283 A1Pre-grant publication · published 28 Jun 2012
Application12/227,861Parent of this division
US 8,148,504 B2Parent of this division
US 2009/0186841 A1Published application
US 8,541,394 B2This patent

From the US filing history. Foreign family members aren’t listed.

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