Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin
AssigneeND Partners, LLC
InventorFrank R. Prosl
Life of this patent
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Abstract
The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective amount of a composition comprising (A) at least one taurinamide derivative, (B) at least one compound selected from the group consisting of biologically acceptable acids and biologically acceptable salts thereof; and (C) heparin at a low concentration.
Claims20
A locking solution composition for treating and reducing infection and flow reduction in blood catheters comprising a solution of:
- a. at least one taurinamide derivative;
- b. a biologically acceptable acid and a biologically acceptable salt of said acid in a combination that brings the pH of the combination into a range that enhances antimicrobial activity of the taurinamide derivative;
- and
- c. heparin in a concentration of 50 to 2500 units per ml, wherein the heparin concentration is sufficient to prevent reactions of the taurinamide derivative with stagnant blood but low enough that expulsion and/or spillage of the solution into a patient's bloodstream carries a low risk of patient hemorrhage.
A method of enhancing the antimicrobial activity and resistance to flow reduction produced by a catheter locking solution comprising taurolidine in combination with citrate and citric acid by maintaining the pH in the range of 5.2 to 6.5 and of protecting a catheter against taurolidine reaction with blood therein by adding heparin in a concentration of 50 to 2500 units per ml, wherein the heparin concentration is sufficient to prevent reactions of the taurolidine with stagnant blood but low enough that expulsion and/or spillage of the solution into a patient's bloodstream carries a low risk of patient hemorrhage.
A composition for treating and reducing infection and patency loss in hemodialysis catheters comprising a locking solution comprising:
- a. at least one taurinamide derivative;
- and
- b. heparin in a concentration of 50 to 2500 units per ml, wherein the heparin concentration is sufficient to prevent reactions of the taurinamide derivative with stagnant blood but low enough that expulsion and/or spillage of the solution into a patient's bloodstream carries a low risk of patient hemorrhage.
A locking solution composition for treating and reducing infection and flow reduction in catheters comprising a solution of:
- a. at least one taurinamide derivative;
- b. a biologically acceptable acid in sufficient concentration to bring the pH of the composition into a range that enhances antimicrobial activity of the taurinamide derivative;
- and
- c. heparin in a concentration of 50 to 2500 units per ml, wherein the heparin concentration is sufficient to prevent reactions of the taurinamide derivative but low enough that expulsion and/or spillage of the solution into a patient's bloodstream carries a low risk of patient hemorrhage.
Dependencies are inferred from the claim text.