Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
AssigneeViroPharma Incorporated
InventorsEugene C. Amparo, Cristina Stoica, Mihaela Pop, Jaroslaw Mazurek
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Abstract
The invention relates to novel crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.
Claims13
Crystalline Form VIII of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole having an X-ray powder diffraction pattern substantially as shown in FIG. 1.
A crystalline form of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole having an X-ray powder diffraction pattern selected from the group consisting of those substantially as shown in FIGS. 2-15.
A crystalline solvate form of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole, including a stoichiometric ratio of an organic solvent within at least one cavity of the crystal lattice, said solvent being selected from the group of methanol, ethyl formate, t-butylmethyl ether, acetonitrile, ethyl acetate, n-propyl acetate, isopropyl acetate, n-butyl acetate, isopropyl ether, 1,2-dimethoxyethane, toluene, 2,2-dimethyl-3-butanone, hexafluorbenzene, nitrobenzene, 1,4-dioxane, tetrahydrofuran (THF), n-heptane, cyclohexane, methylbutyrate, or mixtures thereof.
A composition comprising an admixture of crystalline Form VIII of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole, together with at least one of Form I, Form II, ethanol solvate, Form IV, Form V, Form VI and amorphous 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole.
Dependencies are inferred from the claim text.