Methods for modulating expression of RBP4
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Xing-Xian Yu, Sanjay Bhanot
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Abstract
Methods are provided for modulating RBP4 by administering a RBP4-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the modulation of RBP4. The present invention is also directed to methods of decreasing lipid levels in a subject or for preventing or delaying the onset of a rise in lipid levels in a subject, comprising administering to said subject a RBP4-specific inhibitor.
Claims35
A method of treating or ameliorating a cardiovascular disease in an animal diagnosed as having cardiovascular disease, comprising administering to the animal a therapeutically effective amount of a Retinol-Binding Protein 4 (RBP4) inhibitor, wherein the RBP4 inhibitor is a nucleic acid capable of inhibiting RBP4 by at least 24%, thereby treating or ameliorating the cardiovascular disease in the animal.
A method of decreasing cholesterol levels in a human diagnosed as being in need of decreasing cholesterol levels comprising administering a Retinol-Binding Protein 4 (RBP4) inhibitor to the human diagnosed as being in need of decreasing cholesterol levels, wherein the RBP4 inhibitor is a nucleic acid capable of inhibiting RBP4 by at least 24%, thereby decreasing cholesterol levels in the human.
A method comprising identifying an animal having a cardiovascular disease and administering to said animal a therapeutically effective amount of a composition comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides having a nucleobase sequence complementary to SEQ ID NO:
- 1, 2, 3, 4, 5, 6 or 7 as measured over the entirety of said modified oligonucleotide, wherein the modified oligonucleotide is capable of inhibiting Retinol-Binding Protein 4 (RBP4) by at least 24%, thereby treating the cardiovascular disease.
Dependencies are inferred from the claim text.