Cardiac glycoside analogs in combination with emodin for cancer therapy
AssigneeSirbal Ltd.
InventorNadav Shraibom
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Abstract
A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a combination of emodin and digoxin.
Claims40
A method of treating leukemia, melanoma, or colon, prostate or breast cancer comprising administering to a patient diagnosed with leukemia, melanoma, or colon, prostate or breast cancer a treatment regimen comprising the step of administering periodic doses of an effective amount of digoxin in combination with approximately 5 ug/ml or more of emodin.
The method of 1, wherein the periodic doses comprise more than approximately 10 ug/ml of emodin.
The method of 1, wherein the periodic doses comprise approximately 10 ug/ml emodin.
The method of 1, wherein the periodic doses comprise more than approximately 0.05 ug/ml of digoxin.
The method of 1, wherein the periodic doses comprise approximately 0.1 ug/ml digoxin.
The method of 1, wherein the periodic doses comprise approximately 10 ug/ml of emodin and approximately 0.05 ug/ml or more of digoxin.
The method of 1, wherein the periodic doses comprise approximately 10 ug/ml emodin and approximately 0.10 ug/ml digoxin.
The method of 1, wherein the periodic doses comprise approximately 10 ug/ml or more of emodin and approximately 0.05 ug/ml or more of digoxin.
The method of 1, wherein the periodic doses comprise between approximately 5 and 10 ug/ml of emodin and between approximately 0.05 and 0.1 ug/ml of digoxin.
The method of 1, wherein the treatment regimen comprises twice daily doses.
The method of 1, wherein the treatment regimen comprises daily doses.
The method of 1, wherein the treatment regimen comprises multiple doses per week.
The method of 1, comprising varying doses of each of the emodin and digoxin.
A method of treating leukemia, melanoma, or colon, prostate or breast cancer comprising administering to a patient diagnosed with leukemia, melanoma, or colon, prostate or breast cancer a treatment regimen comprising the step of administering periodic doses of an effective amount of digoxin in combination with approximately 5 ug/ml or more of emodin or the step of administering an effective amount of digoxin in combination with approximately 5 ug/ml or more of emodin with DMSO.
The method of 1, wherein the treatment regimen comprises daily doses.
The method of 1, wherein the treatment regimen comprises multiple doses per week.
The method of 1, wherein the emodin has been extracted from rhubarb root.
The method of 1, wherein the emodin has been extracted from rhubarb, Buckthorn, and/or Japanese Knotweed.
The method of 1, wherein the periodic doses comprise 1.0 ug/ml of digoxin.
The method of 1, wherein the patient has been diagnosed with melanoma.
The method of 1, wherein the patient has been diagnosed with breast cancer.
Dependencies are inferred from the claim text.