C-aryl glucoside SGLT2 inhibitors and pharmaceutical compositions comprising same

A method for preparing the compound of formula (Ih) comprising the steps of:

• subjecting a compound of formula (XII) to a reaction with NaOR11, NaSMe or HNR12R13 (R11, R12R13 are each independently H or C1-4 alkyl);
• a Fe(III)-mediated alkylation using Grignard reagent;
• a Sonogashira reaction with ethynylbenzene;
• a Palladium(0)-catalyzed cyanation under microwave irradiation;
• or a Suzuki-Miyaura coupling with boronic acid, to obtain a compound of formula (XIII);
• and
• removing the benzyl groups of the compound of formula (XIII),
• wherein,
• Ring A is selected from the group consisting of benzene ring, substituted benzene ring, naphthalene ring and substituted naphthalene ring, and
• R14 is C1-4 alkyl, C1-4 alkoxy, —SCH3, phenylethynyl, cyano, amino or aryl.