Isolated extracellular matrix material including subserous fascia
AssigneeCook Biotech Incorporated
InventorsBhavin Shah, Katie L. Harrigan
Life of this patent
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Abstract
Described are purified extracellular matrix materials isolated from the abdominal wall of animals and including the subserous fascia layer of the abdominal wall. Such medical materials can find use in treating damaged tissue and in certain aspects in providing tissue support for the repair of hernias. Related methods of manufacture and use are also described.
Claims25
A bioresorbable collagenous and elastinous extracellular matrix graft material having high elasticity and strength, comprising an isolated, bioresorbable layer of highly extensible extracellular matrix material isolated from the abdominal wall of a porcine animal, said extracellular matrix material comprising collagen and elastin and comprising at least the subserous fascia from the abdominal wall, wherein the extracellular matrix material is essentially devoid of native cells, wherein the extracellular matrix material has a tensile strength at break of at least one pound and an elongation at break of at least about 50%, and wherein the extracellular matrix material has a lipid content of less than 15 percent by weight.
A bioresorbable collagenous and elastinous extracellular matrix graft material having high elasticity and strength, comprising an isolated, bioresorbable layer of highly extensible extracellular matrix material isolated from the abdominal wall of a porcine animal, said extracellular matrix material comprising collagen and elastin and comprising at least the subserous fascia from the abdominal wall, wherein the extracellular matrix material is essentially devoid of native cells, wherein the extracellular matrix material has a tensile strength at break of at least one pound and an elongation at break of at least about 50%, and wherein the extracellular matrix material is free from FGF-2.
A bioresorbable collagenous and elastinous extracellular matrix graft material having high elasticity and strength, comprising two or more isolated, bioresorbable layers of highly extensible extracellular matrix material isolated from the abdominal wall of a porcine animal, wherein said layers are bonded to one another, said extracellular matrix material comprising collagen and elastin and comprising at least the subserous fascia from the abdominal wall, wherein the extracellular matrix material is essentially devoid of native cells, and wherein the extracellular matrix material has a tensile strength at break of at least one pound and an elongation at break of at least about 50%.
Dependencies are inferred from the claim text.