US 8,541,369 B2Granted

Fibroblast growth factor 21 variants having improved pharmacological potency and/or improved pharmaceutical stability

AssigneeEli Lilly and Company

InventorsCraig Duane Dickinson, David Albert Driver, Ryan James Darling, Maigorzata Donata Gonciarz, Radmila Micanovic

Life of this patent

Estimating the term…

Abstract

This present invention relates to pharmacologically potent and/or stable variants of human fibroblast growth factor 21 (FGF21), pharmaceutical compositions comprising FGF21 variants, and methods for treating type 2 diabetes, obesity, dyslipidemia, or metabolic syndrome, or any combination thereof, using such variants.

Claims3

Dependent claims

A variant of human fibroblast growth factor 21 (FGF21), wherein the amino acid sequence is

(SEQ ID NO:
1)
HPIPDSSPLLQFGGQVRQRYLYTDDAQQTECHLEIREDGTVGCAADQSPE
SLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFREDLL
EDGYNVYQSEAHGLPLHLPGDKSPHRKPAPRGPARFLPLPGLPPALPEPP
GILAPQPPDVGSSDPLRLVEPSQLLSPSFLG.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/626,308Filed 25 Sep 2012 · us provisional application
Priority: 4 Oct 2011
Published: US 2013/0085098 A14 Apr 2013
Granted: 24 Sep 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 14/50
Growth factors; Growth regulators: fibroblast growth factor [FGF]
A61K 38/00
Medicinal preparations containing peptides
A61K 38/1825
Growth factors; Growth regulators: fibroblast growth factor [FGF]
A61P 3/00
Drugs for disorders of the metabolism

Family

Application61/542,906Us provisional application · filed 4 Oct 2011
US 2013/0085098 A1Pre-grant publication · published 4 Apr 2013
US 8,541,369 B2This patent

From the US filing history. Foreign family members aren’t listed.

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