Back to results
US 8,541,245 B2Granted
Method for assessing oocyte maturation
AssigneeBeckman Coulter, Inc.
InventorWilliam E. Roudebush
Life of this patent
Estimating the term…
Abstract
The present invention provides methods and kits for assessing the state of oocyte maturation in a female mammal based on the level of PAPP-A found in the female's bodily fluid sample.
Claims23
A method for assessing oocyte maturation in a female, comprising
- detecting pregnancy-associated plasma protein (PAPP-A) level in a bodily fluid from the female, wherein the PAPP-A level of the female is detected daily for a least three consecutive days;
- comparing the PAPP-A level with a control to assess oocyte maturation in the female, the control comprising a previously established baseline PAPP-A level for the bodily fluid of the same female or an average PAPP-A level for the bodily fluid from a healthy fertile non-pregnant female, wherein an increase in the PAPP-A level compared to the control indicates a more advanced state of oocyte maturation and a decrease in the PAPP-A level compared to the control indicates a lesser state of oocyte maturation;
- and
- administering a hormone which induces oocyte maturation to the female within 36 hours after the PAPP-A level in the female exhibits a decrease after continuous increase for at least two consecutive days, the hormone being administered to the female in an amount sufficient to induce final maturation of oocytes in the female.
1 more element
A method for assessing oocyte maturation in a female, comprising
- detecting pregnancy-associated plasma protein (PAPP-A) level in a bodily fluid from the female, wherein the PAPP-A level of the female is detected daily for a least three consecutive days;
- comparing the PAPP-A level with a control to assess oocyte maturation in the female, the control comprising a previously established baseline PAPP-A level for the bodily fluid of the same female or an average PAPP-A level for the bodily fluid from a healthy fertile non-pregnant female, wherein an increase in the PAPP-A level compared to the control indicates a more advanced state of oocyte maturation and a decrease in the PAPP-A level compared to the control indicates a lesser state of oocyte maturation;
- and
- inseminating the female within 36 hours after the PAPP-A level in the female exhibits a decrease after continuous increase for at least two consecutive days.
1 more element
Dependencies are inferred from the claim text.