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US 8,541,234 B2Granted
Methods of generating tendon tissue in vitro from connective tissue progenitor cells
AssigneeTechnion Research & Development Foundation Limited
InventorsJoseph Itskovitz-Eldor, Shahar Cohen
Life of this patent
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Abstract
Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from adult stem cells are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.
Claims15
A method of generating a tendon in vitro, comprising:
- (a) culturing connective tissue progenitor cells in the absence of a scaffold or a carrier to thereby obtain a sheet-like tissue, and
- (b) rolling and/or folding said sheet-like tissue to form a rounded cylinder,
- thereby generating the tendon tissue in vitro.
Dependencies are inferred from the claim text.