Cytoblock preparation system and methods of use

A method of preparing a cytoblock comprising:

• a. preparing a cell pellet in a centrifuge tube having a flattened floor;
• b. combining the prepared cell pellet with a matrix material in the centrifuge to form a cell mixture;
• c. transferring the cell mixture from the centrifuge tube into a tissue cassette having at least one integrally formed chamber that is compatible in size and shape with the bottom region of the centrifuge tube having the flattened floor and processing the mixture;
• and
• d. embedding the processed cell mixture in an embedding block.