Genetic modification for production of 3-hydroxypropionic acid
AssigneeSamsung Electronics Co., Ltd.
InventorsJae Young Kim, Jae Chan Park, Sung Min Park, Hyun Min Koo, Byung Jo Yu, Hwa Young Cho, Young kyoung Park
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Abstract
A method of increasing 3-HP production efficiency by inhibiting expression of a lactate dehydrogenase, a phosphotransacetylase, and an alcohol dehydrogenase in production of 3-HP using a malonic semialdehyde reduction pathway to prevent metabolite leak and increase a malonyl-CoA pool is disclosed.
Claims19
A recombinant microorganism for producing 3-hydroxypropionic acid (3-HP), wherein the recombinant microorganism comprises a metabolic pathway in which metabolites are sequentially produced in a sequence of pyruvate, acetyl-CoA, malonyl-CoA and malonic semialdehyde, and comprises a gene encoding an enzyme that reduces malonyl-CoA into malonic semialdehyde and a gene encoding an enzyme that reduces malonic semialdehyde into 3-HP;
- and wherein the recombinant microorganism has undergone deletion or knockout of a gene encoding at least one selected from the group consisting of lactate dehydrogenase, phosphotransacetylase, and alcohol dehydrogenase.
Dependencies are inferred from the claim text.