Methods and compositions for vaccination
AssigneeSaint Louis University
InventorRobert Mark Buller
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Abstract
The invention provides kits, methods and compositions of matter which improve the safety of vaccination. By combining the administration of antiviral drugs, particularly ester derivatives of cidofovir, with the administration of viral vaccines, particularly the variola vaccine DryVax, side effects of the vaccine are diminished without significantly affecting the effectiveness of the vaccine.
Claims5
A method of vaccinating or immunizing an individual against smallpox virus comprising the steps of administering to an individual a nucleoside analog or a derivative of a nucleoside analog antiviral agent that is cidofovir or an analog of cidofovir and a vaccine or immunizing agent wherein the vaccine or immunizing agent elicits an immune response in the individual and the vaccine or immunizing agent is a live, attenuated smallpox vaccine, wherein the antiviral agent and the vaccine or immunizing agent are co-administered.
A composition comprising a nucleoside analog or a derivative of a nucleoside analog antiviral agent that is cidofovir or an analog of cidofovir and a vaccine or immunizing agent against smallpox virus, wherein the vaccine or immunizing agent elicits an immune response in an individual and the vaccine or immunizing agent is a live, attenuated smallpox virus.
Dependencies are inferred from the claim text.