Surface-independent, surface-modifying, multifunctional coatings and application thereof
AssigneeNorthwestern University
InventorsPhillip B. Messersmith, Haeshin Lee
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Abstract
The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.
Claims14
A method of modifying a substrate surface, the method comprising contacting at least a portion of the substrate with an alkaline solution under oxidative conditions, the solution comprising a surface-modifying agent according to Formula I:
- wherein each of R1, R3, R4 and R5 is independently selected from the group consisting of a thiol, a primary amine, a secondary amine, a nitrile, an aldehyde, an imidazole, an azide, a halide, a hydrogen, a hydroxyl, a carboxylic acid, an aldehyde;
- wherein R2 is NH2;
- wherein x ranges from 0 to 10 and wherein y ranges from 0 to 10, provided that x or y is at least 1;
- wherein the substrate surface is modified when the surface-modifying agent reacts to form a polymeric coat on the substrate surface.
A method of modifying a substrate surface, the method comprising contacting at least a portion of the substrate with an alkaline solution under oxidative conditions, the solution comprising a surface-modifying agent selected from the group consisting of 3,4-dihydroxy-L-phenylalanine (DOPA), 3,4-dihydroxyphenylalanine methyl ester, dopamine, norepinephrine and epinephrine;
- wherein the substrate surface is modified.
Dependencies are inferred from the claim text.