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US 8,541,030 B2Granted
Preparation method of sustained-release microcapsules having initial burst inhibiting property and the microcapsules thereby
AssigneeDongkook Pharmaceutical Co., Ltd.
InventorsNak-Hyun Lim, Jung-Kwoun Kim, Hyung-Joon Jung, Se-Yeon Kim, Goo-Young Jung, Kyung-Hoi Cha, Mork-Soon Park
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Abstract
Disclosed is a method for preparing a longer sustained-release formulation containing bioactive substances. More particularly, the present invention provides a method for preparing longer sustained-release microcapsules comprising: adding an emulsion including bioactive substances, biocompatible polymer and polyvinylpyrrolidone to an aqueous solution.
Claims6
A method for preparing sustained-release microcapsules comprising:
- adding an emulsion containing octreotide or a salt thereof as a bioactive substance, a bio-compatible polymer and polyvinylpyrrolidone to an aqueous solution containing a salt in an amount of 0.02 to 0.15 M to provide the sustained-release microcapsules, wherein the salt is sodium chloride, and wherein the drug encapsulation efficacy of the sustained-release microcapsules is increased in an amount of 15.6% to 40.5% compared to that of a sustained-release microcapsules prepared by an aqueous solution not containing salt.
Dependencies are inferred from the claim text.