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US 8,541,029 B2Granted
Article and method for focused delivery of therapeutic and/or diagnostic materials
AssigneeArmark Authentication Technologies, LLC
InventorsPeter D. Gabriele, Michael S. Flemmens, Jeffrey H. Robertson, Andrew Hogan
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Abstract
A microfiber extrudate and delivery process includes a bio-compatible polymer matrix forming a body of the microfiber extrudate, an exogenously excitable material arranged within the body, and an active load arranged within the body.
Claims15
A microfiber extrudate delivery process comprising:
- identifying a region in an animal;
- medically administering a microfiber extrudate to the region in the animal, the microfiber extrudate comprising:
- a bio-compatible polymer matrix forming a body of the microfiber extrudate;
- a material arranged within the microfiber extrudate body;
- and
- an active load arranged as a discrete domain within the microfiber extrudate body;
- and thereafter
- applying exogenous stimulus to the region in the animal from outside of the animal, thereby releasing the active load from the microfiber extrudate body into the region in the animal;
- wherein the step of applying exogenous stimulus to the material to release the active load comprises applying an exogenous stimulus selected from the group consisting of radiofrequency excitation, microwave excitation, terahertz excitation, mid infrared excitation, near infrared excitation, visible excitation, ultraviolet excitation, x-irradiation excitation, magnetic excitation, electron beam irradiation excitation, and combinations thereof;
- wherein the material is a superparamagnetic iron oxide nano-particle.
7 more elements
A microfiber extrudate delivery process comprising:
- identifying a region in a human;
- medically administering a microfiber extrudate to the region in the human, the microfiber extrudate comprising:
- a polyglycolide copolymer base bio-compatible polymer matrix forming a body of the microfiber extrudate;
- a paramagnetic material arranged within the microfiber extrudate body;
- and
- an active pharmaceutical ingredient arranged as a discrete domain within the microfiber extrudate body;
- and thereafter
- applying radio-frequency stimulation to the region in the human from outside of the human to stimulate the paramagnetic material and release the active load from the microfiber extrudate body into the region in the human;
- wherein the microfiber extrudate is constructed from a micro-extrusion fiber spinning process;
- wherein the step of applying exogenous stimulus to the material to release the active load comprises applying an exogenous stimulus selected from the group consisting of radiofrequency excitation, microwave excitation, terahertz excitation, mid infrared excitation, near infrared excitation, visible excitation, ultraviolet excitation, x-irradiation excitation, magnetic excitation, electron beam irradiation excitation, and combinations thereof;
- wherein the material is a superparamagnetic iron oxide nano-particle.
8 more elements
Dependencies are inferred from the claim text.