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US 8,541,028 B2Granted
Methods for manufacturing delivery devices and devices thereof
AssigneeEvonik Corporation
InventorsJay K. Staas, Thomas R. Tice, Bruce W. Hudson, Arthur J. Tipton
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Abstract
Described herein are methods for reducing and achieving the desired release of an agent from a delivery system. The desired release kinetics are achieved by exposing the surface of the delivery system with a fluid for a desired period of time.
Claims18
A method for preparing a device comprising an agent, comprising
- (a) admixing at least one polymer and at least one agent to produce an admixture;
- (b) processing the admixture to produce a device of a desired shape, wherein the device comprises at least two exposed surfaces;
- and
- (c) contacting the device with a sufficient amount of a fluid for a sufficient time to change the surface morphology of the polymer;
- wherein the fluid diffuses into the outer layer of the polymer to gel the polymer thereby producing a smoother surface coating on the device, wherein at least one exposed surface or least one part of at least one exposed surface of the device is not contacted with the fluid;
- wherein steps (a) and (b) do not involve the use of a solvent;
- and
- wherein the fluid consists essentially of methylene chloride, chloroform, acetone, anisole, methyl acetate, ethyl acetate, N-methyl-2- pyrrolidone, hexafluoroisopropanol, tetrahydrofuran, dimethylsulfoxide, 2-pyrollidone, triethyl citrate, ethyl lactate, propylene carbonate, benzyl alcohol, benzyl benzoate, Miglyol 810, isopropanol, ethanol, super critical carbon dioxide, or acetonitrile, or a mixture thereof.
5 more elements
Dependencies are inferred from the claim text.