US 8,541,021 B2 · Hydrogel compositions demonstrating phase separation on contact with aqueous media

Abstract

A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer or a water-soluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer. The composition also includes a second water-swellable, water-insoluble polymer that provides for a phase separating film forming composition. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening, and removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Claims43

Dependent claims

A body surface contacting composition comprising:

(a) a first water-swellable acrylate-based polymer having a pH-dependent solubility and insoluble in water at a pH less than about 5.5,
(b) a blend of a poly(N-vinyl lactam) and a complementary oligomer capable of hydrogen bonding to the poly(N-vinyl lactam);
and
(c) a second water-swellable acrylate-based polymer that is insoluble in water independent of pH;
in a solvent or mixture of solvents,
wherein the weight ratio of the first to second water-swellable acrylate-based polymers is in a range of about 1.5:1 to 2:1 and the poly(N-vinyl lactam) represents about 1-30 weight percent of the composition, such that when the composition is placed in an aqueous environment at a pH of from about 6-8, the second water-swellable acrylate-based polymer forms a film over the remainder of the composition.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/848,538Filed 17 May 2004 · continuation in part

Priority

1 May 2001

Published

US 2004/0258723 A123 Dec 2004

Granted

24 Sep 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 8/042
Dispersions; Emulsions: gels
A61C 19/063
Implements for therapeutic treatment: medicament applicators for teeth or gums, e.g. treatment with fluorides
A61C 19/066
Medicament applicators for teeth or gums, e.g. treatment with fluorides: bleaching devices; Whitening agent applicators for teeth, e.g. trays or…
A61K 6/69
Comprising organic or organo-metallic additives: medicaments

Family

Application60/288,008Us provisional application · filed 1 May 2001

Application10/137,664Parent of this continuation-in-part · filed 1 May 2002

Application10/359,548Parent of this continuation-in-part · filed 5 Feb 2003

Application10/442,020Parent of this continuation-in-part · filed 19 May 2003

US 2004/0258723 A1Pre-grant publication · published 23 Dec 2004

US 2003/0152528 A1Published application

US 2003/0170308 A1Published application

US 2003/0235549 A1Published application

US 8,728,445 B2Related patent

US 8,840,918 B2Related patent

US 8,541,021 B2This patent

From the US filing history. Foreign family members aren’t listed.

Hydrogel compositions demonstrating phase separation on contact with aqueous media

Life of this patent

Hydrogel compositions demonstrating phase separation on contact with aqueous media

Life of this patent

Abstract

Claims43