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AssigneeTemasek Life Sciences Laboratory Limited
InventorsYuen Fern Ho, Qing Yun Du, Fang He, Jimmy Hwei-Sing Kwang
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The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected in formalin preserved, paraffin embedded specimens as well as frozen specimens and biological fluids. Accordingly, the invention provides for the diagnosis and surveillance of dangerous viral infections.
An isolated monoclonal antibody 6B8 as produced by hybridoma 6B8 which is deposited with the American Type Culture Collection with Accession Number PTA-8246.
A method for detecting H5 subtype avian influenza virus in a biological specimen which comprises contacting the biological specimen with monoclonal antibody 6B8, as produced by hybridoma 6B8 which is deposited with the American Type Culture Collection with Accession Number PTA-8246 and detecting binding of said monoclonal antibody.
A kit for detecting H5 subtype avian influenza virus in a biological specimen which comprises
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