Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody

A composition for neutralizing botulinum toxin type-A comprising:

• a first human anti-botulinum toxin type-A antibody that recognizes an epitope which is recognized by an antibody having a heavy chain variable region (VH) comprising the amino acid sequence of SEQ ID NO:
• 4 and a light chain variable region (VL) comprising the amino acid sequence of SEQ ID NO:
• 8;
• a second human anti-botulinum toxin type-A antibody that recognizes an epitope which is recognized by an antibody having a VH comprising the amino acid sequence of SEQ ID NO:
• 36 and a VL comprising the amino acid sequence of SEQ ID NO:
• 40;
• and
• a third human anti-botulinum toxin type-A antibody that recognizes an epitope which is recognized by an antibody having a VH comprising the amino acid sequence of SEQ ID NO:
• 44 and a VL comprising the amino acid sequence of SEQ ID NO:
• 48, or that recognizes an epitope which is recognized by an antibody having a VH comprising the amino acid sequence of SEQ ID NO:
• 52 and a VL comprising the amino acid sequence of SEQ ID NO:
• 56.