Use of Hsp70 as a regulator of enzymatic activity
AssigneeOrphazyme ApS
InventorsThomas Kirkegaard Jensen, Marja Helena Jaattela
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Abstract
The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.
Claims11
A method for treatment of a lysosomal storage disorder selected from the group consisting of Niemann-Pick type A, Niemann-Pick type B, Niemann-Pick type C and Niemann-Pick type D, comprising the administration of a bioactive agent selected from Hsp70, a functional fragment of Hsp70 or variant thereof having at least 95% sequence identity to Hsp70, to an individual in need thereof.
Dependencies are inferred from the claim text.