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AssigneeSloan-Kettering Institute for Cancer Research
InventorsPhilip O. Livingston, Govindaswami Ragupathi, Samuel J. Danishefsky
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This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. This invention also provides a multivalent vaccine comprising at least two of the following: glycosylated MUC-1-32mer, Globo H, GM2, Ley, Tn(c), sTN(c), and TF(c). This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant. This invention provides a method for inducing immune response in a subject comprising administering an effective amount of the vaccine above to the subject. Finally, this invention provides a method for treating cancer in a subject comprising administering an appropriate amount of the vaccine above to the subject.
An immunogenic composition comprising an adjuvant and antigens comprising MUC-1, Tn, GloboH and TF(c), and said composition further comprising at least one antigen selected from the group consisting of sTn(c), Tn(c) and sialyl Lea, wherein said antigens are individually conjugated to a carrier.
An immunogenic composition comprising an adjuvant and antigens comprising MUC1-Tn conjugate, GloboH and TF(c), and said composition further comprising at least one antigen selected from the group consisting of sTn(c), Tn(c) and sialyl Lea, wherein said conjugate and each of said antigens are individually conjugated to a carrier.
A method for inducing antibody production in a subject comprising administering an immunogenic composition comprising antigens comprising MUC1-Tn conjugate, GloboH and TF(c), wherein said conjugate and each of said antigens are individually conjugated to a carrier.
Dependencies are inferred from the claim text.