Preparation for magnesium ammonium phosphate cements

A process for the production of a magnesium ammonium phosphate cement using a composition comprising:

• (a) mixing magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0 with ammonium salt and water or with an aqueous solution of the ammonium salt until a homogenous mixture is obtained;
• (b) applying the homogenous mixture to a target object;
• and
• (c) causing the homogenous mixture to harden, thereby obtaining set magnesium ammonium phosphate cement.

A composition for a magnesium ammonium phosphate cement comprising:

• (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0, wherein the magnesium calcium phosphate is selected from the group consisting of sintered magnesium calcium phosphate, powdered magnesium calcium phosphate having a mean particle size in the range of 0.5 to 10 μm, Mg2.25Ca0.75(PO4)2, Mg2.5Ca0.5(PO4)2, and Mg2.75Ca0.25(PO4)2;
• (b) an ammonium salt, wherein the ammonium salt is selected from the group consisting of monoammonium salts of phosphoric acid, monoammonium salts of citric acid, monoammonium salts of tartaric acid, monoammonium salts of sulfuric acid, monoammonium salts of acetic acid, diammonium salts of phosphoric acid, diammonium salts of citric acid, diammonium salts of tartaric acid, diammonium salts of sulfuric acid, diammonium salts of acetic acid, and mixtures thereof, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, and a mixture of diammonium hydrogen phosphate and ammonium dihydrogen phosphate;
• (c) water;
• and,
• (d) at least one of the group comprising pharmaceutically active ingredients, viscosity affecting excipients, pore forming excipients, injectivity affecting excipients, cohesion affecting excipients, paste consistency affecting excipients, porosity affecting excipients, resorptivity affecting excipients, adhesion to the bone affecting excipients, stability in storage affecting excipients, compatibility with active ingredients affecting excipients, and release affecting excipients.