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US 8,540,416 B2Granted
Fluidic flow merging apparatus
AssigneesCapitalBio Corporation, Tsinghua University
InventorsXiaosheng Guan, Min Guo, Cheng Zhou, Yuming Hu, Jing Cheng
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Abstract
The present invention provides a device for handling fluids, and more particularly a merging apparatus for fluidic and microfluidic devices utilizing passive valving in conjunction with a single sensor to uniformly blend contributory working fluid streams. Symmetric and non symmetric embodiments with and without branch channels are described. The present invention also provides methods for merging liquids using the device of the invention.
Claims8
A microfluidic flow merging apparatus comprising:
- first and second tributary channels;
- an effluent channel;
- a junction formed at the joining of the first and second tributary channels, and the effluent channel;
- a flow obstruction formed within the junction;
- at least one fluid sensor configured proximate to the junction to sense the presence of working fluids;
- a pressure pump configured to drive a working fluid flow in one of the tributary channels;
- and
- a controller configured to be in operable communication with the fluid sensor and the pressure pump,
- wherein the first and second tributary channels, the effluent channel, the junction, and the flow obstruction are formed by walls comprising a hydrophilic material, and wherein the controller is configured to control the pressure pump responsive to a signal from the fluid sensor.
6 more elements
A microfluidic flow merging apparatus comprising:
- a first tributary channel;
- a branching channel, joined to the first tributary channel at a first junction;
- a second tributary channel joined to the first tributary channel at a second junction;
- an intermediate effluent channel joined to the first tributary channel and the second tributary channel at the second junction;
- an effluent channel, joined to the intermediate effluent channel and the branching channel at a third junction but not jointed to the first tributary channel or the second tributary channel;
- at least one fluid sensor configured proximate to the second junction to sense the presence of working fluids;
- a pressure pump configured to drive a working fluid flow in one of the tributary channels;
- and
- a controller configured to be in operable communication with the fluid sensor and the pressure pump,
- wherein the first and second tributary channels, the branching channel, the intermediate effluent channel, the effluent channel, the first, second and third junctions, are formed by walls comprising a hydrophilic material, and wherein the controller is configured to control the pressure pump responsive to a signal from the fluid sensor.
7 more elements
A microfluidic flow merging apparatus comprising:
- a first tributary channel;
- a first intermediate tributary channel
- a first branching channel, joined to the first tributary channel and the first intermediate tributary channel at a first junction;
- a second tributary channel;
- a second intermediate tributary channel;
- a second branching channel, joined to the second tributary channel and the second intermediate tributary channel at a second junction;
- a third junction joining the first and second branching channels;
- an effluent channel;
- a fourth junction joining the first intermediate tributary channel, the second intermediate tributary channel, and the effluent channel;
- first and second fluid sensors configured proximate to the first and second tributary channels, respectively, to sense the presence of working fluids;
- a pressure pump configured to drive a working fluid flow in one of the tributary channels;
- and
- a controller configured to be in operable communication with the fluid sensor and the pressure pump,
- wherein the first and second tributary channels, the first and second branching channels, the first and second intermediate tributary channels, the intermediate effluent channel, the effluent channel, and the first, second, third and fourth junctions, are formed by walls comprising a hydrophilic material, and wherein the controller is configured to control the pressure pump responsive to a signal from at least one of the first and second fluid sensors.
11 more elements
Dependencies are inferred from the claim text.