Methods and compositions for inhibiting diseases of the central nervous system

An isolated composition comprising:

• a) an immunogen, wherein said immunogen induces a humoral immune response against at least one abnormal protein of a central nervous system disease or disorder, and
• b) at least one adjuvant that stimulates regulatory T cells,
• wherein said immunogen consists of nitrated alpha synuclein or a fragment thereof,
• wherein said nitrated alpha synuclein fragment is a carboxy terminal fragment consisting of the carboxy terminal 20 amino acids of alpha synuclein up to the carboxy terminal 70 amino acids of alpha synuclein.