US 8,480,975 B2Granted

Structures for controlling light interaction with microfluidic devices

AssigneeOPKO Diagnostics, LLC

InventorsDavid Steinmiller, Vincent Linder

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Abstract

Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.

Claims38

Dependent claims

A fluidic device comprising:

an article including first and second sides;
first and second adjacent microfluidic channel segments positioned at the first side of the article;
an intervening portion positioned substantially between the first and second microfluidic channel segments;
and
a first optical element positioned at the second side of the article and positioned substantially between the first and second channel segments,
wherein the first optical element is adapted and arranged such that when a portion of the article is exposed to light at a first intensity, the first optical element redirects at least a portion of the light away from the intervening portion, such that the intervening portion is not exposed to the light or is exposed to the light at a second intensity lower than an intensity of the light at the intervening portion absent the first optical element.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/490,055Filed 6 Jun 2012 · continuation
Priority: 2 Feb 2009
Published: US 2012/0237401 A120 Sep 2012
Granted: 9 Jul 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification23 codes

B01L 3/502707
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/5027
With fluid transport, e.g. in multi-compartment structures: by integrated microfluidic structures, i.e. dimensions of channels and chambers are…
B01L 3/502715
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
C12Y 304/21077
Serine endopeptidases: semenogelase , i.e. prostate specific antigen or PSA or kallikrein 3

Family

Application61/149,253Us provisional application · filed 2 Feb 2009
Application12/698,451Parent of this continuation · filed 2 Feb 2010
US 8,221,700 B2Parent of this continuation · filed 17 Jul 2012
US 2012/0237401 A1Pre-grant publication · published 20 Sep 2012
US 2010/0196207 A1Published application
US 8,480,975 B2This patent

From the US filing history. Foreign family members aren’t listed.

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