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US 8,465,929 B2Granted
Biomarkers for ovarian cancer
AssigneesVermillion, Inc., University of Kentucky Research Foundation
InventorsEric T. Fung, Frederick R. Ueland, J. R. van Nagell, Paul D. Depriest, Andre T. Baron
Life of this patent
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Abstract
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry.
Claims19
A method for qualifying ovarian cancer status in a subject comprising:
- (a) measuring Calcyclin, Calgranulin C and Hepcidin in an ovarian cyst fluid, urine, or serum sample from the subject by mass spectrometry or immunoassay to determine the presence, absence, or level of the measured Calcyclin, Calgranulin C and Hepcidin biomarkers, and
- (b) correlating the measurements of the presence, absence, or level of the measured Calcyclin, Calgranulin C and Hepcidin biomarkers with ovarian cancer status.
Dependencies are inferred from the claim text.