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US 8,465,918 B2Granted
Ultraconserved regions encoding ncRNAs
AssigneeThe Ohio State University Research Foundation
InventorCarlo M. Croce
Life of this patent
Estimating the term…
Abstract
Described herein are methods for differentiate human cancers comprising using one or more transcribed ultraconserved regions (T-UCR) expression profiles where the association between the genomic location of UCRs and the analyzed cancer-related genomic elements is highly statistically significant and comparable to that reported for miRNAs.
Claims3
A method to identify a relative risk in a vertebrate for developing chronic lymphocytic leukemia, comprising:
- (a) obtaining a nucleic acid-containing test sample from a vertebrate subject,
- (b) measuring, by laboratory analysis, a level of at least one transcribed ultra-conserved regions (T-UCR),
- (c) identifying whether the test sample expresses at least one T-UCR,
- (d) determining the relative risk for developing chronic lymphocytic leukemia by comparing the at least one T-UCR measured level to the level of a corresponding T-UCR in a control sample,
- wherein a decrease in the level of at least one T-UCR in the test sample, relative to the level of a corresponding T-UCR in a control sample, is indicative of the subject either having, or being at risk for developing chronic lymphocytic leukemia, wherein the at least one T-UCR is uc.160(N), and
- (e) measuring the level of at least one miR-155 in the test sample from said subject,
- wherein an increase in the level of the miR-155 in the test sample, relative to the level of a corresponding miR-155 in a control sample, is indicative of the subject either having, or being at risk for developing chronic lymphocytic leukemia.
4 more elements
Dependencies are inferred from the claim text.