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US 8,465,770 B2Granted
Low dose controlled release tablet
AssigneeSynthon BV
InventorsKorinde Annemarie Jansen, Dirk Pamperin
Life of this patent
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Abstract
Low dose pharmaceuticals can be delivered for a prolonged period using a tablet-in-tablet design wherein the drug is contained in a controlled release matrix in the outer compression coating layer but not in the inner tablet core.
Claims22
A controlled release pharmaceutical tablet, comprising:
- (a) an inner tablet core having a size within the range of 3 to 7 mm and comprising at least one pharmaceutically acceptable excipient but substantially free from any pharmaceutically active agent;
- and
- (b) an outer compression coating layer surrounding said inner tablet core and which comprises a controlled release matrix having a pharmaceutically active agent dispersed therein;
- wherein the total amount of pharmaceutically active agent contained in said tablet is within the range of 0.1 to 5 mg.
1 more element
A controlled release tamsulosin tablet comprising:
- (a) an inner tablet core having a size within the range of 3 to 7 mm and comprising at least one pharmaceutically acceptable excipient and substantially free from any pharmaceutically active agent;
- and
- (b) an outer compression coating layer surrounding said inner tablet core and which comprises 0.1 to 2 mg of tamsulosin or salt thereof dispersed in a water-swellable matrix comprising (i) at least one pH-sensitive swellable hydrophilic polymer, which is a cross-linked polyacrylic acid polymer, and (ii) at least one pH-insensitive swellable hydrophilic polymer;
- and optionally a water insoluble binder.
1 more element
Dependencies are inferred from the claim text.