Nanoemulsion of resveratrol-phospholipid complex and method for preparing the same and applications thereof

A method for preparing a nanoemulsion comprising the following steps:

• (1) stirring a mixture of 1 part by weight of resveratrol, 10-20 parts by weight of phospholipid and 0.5-5 parts by weight of a solvent at 20-60° C. until a transparent oily homogeneous liquid is obtained, wherein the solvent is at least one member selected from a group consisting of ethanol, acetone, ethyl acetate, methanol, and ethyl ether;
• (2) removing the solvent from the homogeneous liquid obtained in step (1) by vacuum distillation at 20-50° C. to form a resveratrol-phospholipid complex;
• (3) adding the resveratrol-phospholipid complex obtained in step (2) into 30-490 parts by weight of an aqueous solution of polyol at 20-60° C. temperature, and mixing by stirring in the meantime of the addition of the resveratrol-phospholipid complex into the aqueous solution, thereby forming a crude dispersion of resveratrol-phospholipid complex;
• (4) homogenizing the crude dispersion obtained in step (3) with a high-pressure homogenizer or a Microfluidizer homogenizer for 2-10 times under a pressure of 200 bar to 1500 bar, thereby making the particle diameter of the resveratrol-phospholipid complex less than 200 nm.