Combination vaccines against Mycobacterium sp. and methods of using the same
OwnerRobert J. Greensteininventor
Life of this patent
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Abstract
The invention relates to a combination vaccine against Mycobacterium avium subspecies paratuberculosis (MAP) and M. tuberculosis and/or M. bovis for use in methods of immunizing a subject against mycobacterial infection, preventing or treating mycobacterial infection, and preventing a disease associated with mycobacterial infection.
Claims11
A method for producing a vaccine for immunizing a subject against Mycobacterium avium subspecies paratuberculosis (MAP) and M. tuberculosis (MTB) infection comprising admixing
- (a) at least one isolated and purified MAP antigen, or attenuated or killed MAP, wherein the MAP antigen is GroES, AhpD, 32 kDa antigen, 34 kDa antigen, 34.5 kDa antigen, 35 kDa antigen, 36 kDa antigen, 42 kDa antigen, 44.3 kDa antigen, 65 kDa antigen or AhpC antigen and the attenuated or killed MAP is cell wall-competent or cell wall-deficient;
- (b) at least one MTB antigen, or an attenuated or killed MTB;
- and
- (c) a suitable carrier
- thereby producing a vaccine for the immunization against MAP and MTB infection.
A method for immunizing a subject against Mycobacterium avium subspecies paratuberculosis (MAP) and M. tuberculosis (MTB) infection comprising administering to a subject a vaccine containing
- (a) at least one isolated and purified MAP antigen, or attenuated or killed MAP, wherein the MAP antigen is GroES, AhpD, 32 kDa antigen, 34 kDa antigen, 34.5 kDa antigen, 35 kDa antigen, 36 kDa antigen, 42 kDa antigen, 44.3 kDa antigen, 65 kDa antigen or AhpC antigen and the attenuated or killed MAP is cell wall-competent or cell wall-deficient;
- and
- (b) at least one MTB antigen, or an attenuated or killed MTB,
- thereby immunizing the subject against MAP and MTB infection.
A method for treating Mycobacterium avium subspecies paratuberculosis (MAP) and M. tuberculosis (MTB) infection comprising administering to a subject a vaccine containing
- (a) at least one isolated and purified MAP antigen, or attenuated or killed MAP;
- and
- (b) at least one MTB antigen, or an attenuated or killed MTB,
- thereby treating MAP and MTB infection.
A method for preventing a disease associated with Mycobacterium avium subspecies paratuberculosis (MAP) and M. tuberculosis (MTB) infection comprising administering to a subject a vaccine containing
- (a) at least one attenuated or killed MAP, wherein the attenuated or killed MAP is cell wall-competent or cell wall-deficient;
- (b) at least one MTB antigen, or an attenuated or killed MTB,
- thereby preventing a disease associated with MAP and MTB infection.
A method for preventing a disease associated with Mycobacterium avium subspecies paratuberculosis (MAP) and M. tuberculosis (MTB) infection comprising administering to a subject a vaccine containing
- (a) at least one isolated and purified MAP antigen, wherein the MAP antigen is GroES, AhpD, 32 kDa antigen, 34 kDa antigen, 34.5 kDa antigen, 35 kDa antigen, 36 kDa antigen, 42 kDa antigen, 44.3 kDa antigen, 65 kDa antigen or AhpC antigen;
- (b) at least one MTB antigen, or an attenuated or killed MTB,
- thereby preventing a disease associated with MAP and MTB infection.
A vaccine comprising
- (a) at least one isolated and purified Mycobacterium avium subspecies paratuberculosis (MAP) antigen, or attenuated or killed MAP, wherein the MAP antigen is GroES, AhpD, 32 kDa antigen, 34 kDa antigen, 34.5 kDa antigen, 35 kDa antigen, 36 kDa antigen, 42 kDa antigen, 44.3 kDa antigen, 65 kDa antigen or AhpC antigen and the attenuated or killed MAP is cell wall-competent or cell wall-deficient;
- (b) at least one isolated and purified antigen from a member of the M. tuberculosis complex (MTC), or an attenuated or killed mycobacterium from the MTC;
- and
- (c) a suitable carrier.
A vaccine consisting of:
- (a) at least one attenuated or killed Mycobacterium avium subspecies paratuberculosis (MAP), wherein the attenuated or killed MAP is cell wall-competent or cell wall-deficient;
- (b) at least one isolated and purified antigen from a member of the M. tuberculosis complex (MTC), or an attenuated or killed mycobacterium from the MTC;
- and
- (c) a suitable carrier.
A vaccine consisting of:
- (a) at least one Mycobacterium avium subspecies paratuberculosis (MAP) antigen, wherein the MAP antigen is GroES, AhpD, 32 kDa antigen, 34 kDa antigen, 34.5 kDa antigen, 35 kDa antigen, 36 kDa antigen, 42 kDa antigen, 44.3 kDa antigen, 65 kDa antigen or AhpC antigen;
- (b) at least one isolated and purified antigen from a member of the M. tuberculosis complex (MTC), or an attenuated or killed mycobacterium from the MTC;
- and
- (c) a suitable carrier.
Dependencies are inferred from the claim text.