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US 8,465,751 B2Granted
Cna—B domain antigens in vaccines against gram positive bacteria
AssigneeNovartis AG
InventorsAndrea Guido Oreste Manetti, Immaculada Margarit Y Ros, Guido Grandi
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Abstract
The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
Claims17
A Cna_B domain antigen selected from the group consisting of:
- (a) a Cna_B domain antigen comprising the amino acid sequence SEQ ID NO:5, wherein amino acid 1 of SEQ ID NO:5 is not linked by a peptide bond to amino acid 311 of SEQ ID NO:21 and/or amino acid 70 of SEQ ID NO:5 is not linked by a peptide bond to amino acid 382 of SEQ ID NO:21;
- (b) a Cna_B domain antigen which consists of the amino acid sequence SEQ ID NO:5 and 307, 308, 309, or 310 additional contiguous amino acids of SEQ ID NO:21 at the N terminus of SEQ ID NO:5;
- and
- (c) a Cna_B domain antigen which consists of the amino acid sequence SEQ ID NO:5 and 307, 308, 309, or 310 additional contiguous amino acids of SEQ ID NO:21 at the N terminus of SEQ ID NO:5 and 0-380 additional contiguous amino acids of SEQ ID NO:21 at the C terminus of SEQ ID NO:5, and wherein the Cna B domain antigen is not a native gram positive bacterial protein, SEQ ID NO:21.
1 more element
Dependencies are inferred from the claim text.