Regulatory T cell mediator proteins and uses thereof
AssigneeTrustees of Dartmouth College
InventorsRandolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
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Abstract
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
Claims6
A method of promoting T cell immunity against a viral infectious agent comprising administering an effective amount of an anti-PD-L3 antibody or antibody fragment that specifically binds to the extracellular region of the human PD-L3 protein having the sequence in SEQ ID NO:4, wherein said anti-PD-L3 antibody or antibody fragment antagonizes the immunosuppressive effect of PD-L3 on T cell immunity in vivo, and thereby potentiates T cell immune response against the viral infectious agent.
Dependencies are inferred from the claim text.