US 8,465,707 B2Granted

Composite liquid cells

AssigneeGencell Biosystems Ltd.

InventorsKieran Curran, Paul Fleming, Séamus Gillhooley, Micheál Keane, Inga Rosca, Patrick Tuohy

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Abstract

A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in a carrier-liquid conduit comprising a stabilisation feature and (b) proximate to the stabilisation feature, the encapsulating liquid being immiscible with the carrier liquid, so that the discharged encapsulating liquid does not mix with the carrier liquid, floats on top of the carrier liquid, and is immobilised by the stabilisation feature; drawing a sample liquid from a sample-liquid input; and discharging the drawn sample liquid, the sample liquid being immiscible with the encapsulating liquid and with the carrier liquid, so that the sample liquid does not mix with the encapsulating liquid or with the carrier liquid.

Claims15

Dependent claims

A sample handling system comprising:

a sample-liquid input;
an encapsulating-liquid input;
a carrier-liquid conduit comprising a stabilisation feature;
a liquid-handling system;
and
a controller operably connected to the liquid-handling system;
wherein the controller is programmed to cause the liquid-handling system to:
(1) draw an encapsulating liquid from the encapsulating-liquid input;
(2) discharge the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in the carrier-liquid conduit and (b) proximate to the stabilisation feature, the encapsulating liquid being immiscible with the carrier liquid, so that the discharged encapsulating liquid does not mix with the carrier liquid, floats on top of the carrier liquid, and is immobilised by the stabilisation feature;
(3) draw a sample liquid from the sample-liquid input;
and
(4) discharge the drawn sample liquid, the sample liquid being immiscible with the encapsulating liquid and with the carrier liquid, so that the sample liquid does not mix with the encapsulating liquid or with the carrier liquid.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/147,679Filed 22 Jul 2011 · us provisional application
Priority: 22 Jul 2010
Published: US 2012/0045765 A123 Feb 2012
Granted: 18 Jun 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification38 codes

C12Q 1/6806
Involving nucleic acids: preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
B01F 23/41
Mixing liquids with liquids; Emulsifying: emulsifying
B01F 33/3021
The materials to be mixed flowing in the form of droplets: the components to be mixed being combined in a single independent droplet, e.g. these…
B01L 3/0293
Apparatus for withdrawing or distributing predetermined quantities of fluid: for liquids

Family

Application61/344,434Us provisional application · filed 22 Jul 2010
Application61/470,515Us provisional application · filed 1 Apr 2011
Application61/470,520Us provisional application · filed 1 Apr 2011
US 2012/0045765 A1Pre-grant publication · published 23 Feb 2012
US 8,465,707 B2This patent

From the US filing history. Foreign family members aren’t listed.

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