Monolith separation medium for chromatography and process for producing the same

A monolith separation column for chromatography comprising:

• a capillary tube;
• a skeletal phase of an organic macromolecular gel-like monolith formed in the capillary tube;
• a pore formed by the skeletal phase and being continuous in the form of three-dimensional network;
• and
• a functional group present on the surface of the skeletal phase and permitting introduction of a new functional group,
• wherein the skeletal phase has an average diameter of submicron to micrometer size, has a non-particle-aggregation-type co-continuous structure, is constituted of an addition polymer from 2,2,2-tri-(2,3-epoxypropyl)-isocyanurate as an epoxy compound and an amine compound having two or more amino groups in a molecule, and does not contain any carbon atom constituting an aromatic compound, and
• wherein the monolith separation column is obtained by:
• (A) filling the epoxy compound, the amino compound and a porogen into a capillary tube;
• (B) heating the epoxy compound and the amine compound within a range of from 60 to 200° C. in the porogen to polymerize them to obtain a gel-like material in the capillary tube, and
• (C) then washing the gel-like material with a solvent to remove the porogen to leave the skeletal phase in the capillary tube.