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US 8,465,542 B2Granted
Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
AssigneeThe Children's Hospital of Philadelphia
InventorsRobert J. Levy, Ivan Alferiev, Stanley J. Stachelek
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Abstract
A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
Claims4
An implant produced by a process comprising the steps of:
- providing a modified polyurethane comprising a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, wherein the lipid substituent is a thiol-modified cholesterol substituent or an amino-modified cholesterol substituent
- forming an article from the modified polyurethane;
- and
- contacting the article with cells to attach the cells to the lipid substituent and thereby attach the cells to the article to form the implant, provided that a portion of the cells remains attached to the implant when exposed to a fluid-induced shear stress.
1 more element
Dependencies are inferred from the claim text.