Bodily lumen closure apparatus and method

A method for closing a passageway in a body of a patient, comprising:

• providing a closure device that includes an isolated remodelable collagenous extracellular matrix sheet material isolated as a sheet material from a collagenous-based tissue source, the remodelable collagenous extracellular matrix sheet material being rolled or folded to provide a closure device construct in which the remodelable collagenous extracellular matrix sheet material spans the entirety of the length of the closure device construct and where, prior to delivery, extracellular matrix material extends across the full width of the closure device construct with adjacent layers of the extracellular matrix sheet material situated in the center of the closure device construct, the remodelable collagenous extracellular matrix sheet material being effective upon implantation to provide new tissue growth in the body passageway for closing the body passageway with tissue of the patient, wherein said adjacent layers of the extracellular matrix sheet material contact one another in the closure device construct;
• and
• inserting the closure device in the body passageway so as to close the body passageway, wherein said inserting is conducted without advancing the closure device over a delivery device, wherein the closure device is sized and configured to close the body passageway without folding the closure device upon itself, and wherein the body passageway is a fistula.