Apparatus and methods for occluding a hollow anatomical structure

A device for implantation into a patient and occluding a left atrial appendage of the heart of the patient, the device comprising:

• a clamp having at least first and second clamping portions configured to be implanted and placed on opposite sides of the left atrial appendage, at least one of said first and second clamping portions being movable toward the other of said first and second clamping portions from an open position into a clamping position to occlude the left atrial appendage, said first and second clamping portions being held in the clamping position under a spring bias, and having first and second ends spaced apart from each other along a longitudinal direction of said clamp,
• said first and second clamping portions joined together proximate said first and second ends, whereby said first and second clamping portions and said first and second ends define a closed shape, and
• a fabric covering on at least one of said first and second clamping portions, said fabric covering extending completely around an outer peripheral surface of each of said first and second clamping portions and said first and second ends,
• said fabric covering adapted to be implanted in the patient and constructed to promote tissue ingrowth while implanted for retaining the clamp in place on the left atrial appendage.

An apparatus for implantation into a patient and occluding a left atrial appendage of the heart of the patient, the apparatus comprising:

• a clamp having at least first and second clamping portions configured to be implanted and placed on opposite sides of the left atrial appendage, at least one of said first and second clamping portions being movable toward the other of said first and second clamping portions from an open position into a clamping position to occlude the left atrial appendage, said clamp having first and second ends spaced apart from each other along a longitudinal direction of said clamp,
• said first and second clamping portions joined together proximate said first and second ends, whereby said first and second clamping portions and said first and second ends define a closed shape,
• a fabric covering on said first and second clamping portions, said fabric covering extending completely around an outer peripheral surface of each of said first and second clamping portions and said first and second ends,
• said fabric covering adapted to be implanted in the patient and constructed to promote tissue ingrowth while implanted for retaining the clamp in place on the left atrial appendage, and
• a delivery and actuation device releasably coupled with said clamp and capable of actuating said clamp between the open position and the clamping position.

An apparatus for implantation into a patient and occluding a left atrial appendage of the heart of the patient, the apparatus comprising:

• a clamp having at least first and second clamping portions configured to be implanted and placed on opposite sides of the left atrial appendage, at least one of said first and second clamping portions being movable toward the other of said first and second clamping portions from an open position into a clamping position to occlude the left atrial appendage,
• a fabric covering on said first and second clamping portions, said fabric covering adapted to be implanted in the patient and constructed to promote tissue ingrowth while implanted for retaining the clamp in place on the left atrial appendage, and
• a delivery and actuation device releasably coupled with said clamp and capable of actuating said clamp between the open position and the clamping position,
• wherein said clamp is coupled to said delivery and actuation device with suture.