Providing cryotherapy with a balloon catheter having a non-uniform thermal profile

A cryotherapy catheter comprising:

• an elongate member and an inflatable balloon portion at a distal end of the elongate member, the inflatable balloon portion having an external surface and an interior chamber and comprising an inner balloon and an outer balloon;
• the external surface comprising a cooling region and a thermally insulated region;
• the interior chamber configured to receive during a cryotherapy procedure a cryogenic agent for extracting heat from body tissue that is in contact with the cooling region;
• and
• an insulative material disposed between the inner balloon and the outer balloon, or adjacent to a surface of at least one of the inner balloon or the outer balloon;
• the insulative material comprising a material having at least one of a plurality of air pockets formed therein or a plurality of hollow beads disposed therein;
• wherein the insulative material is disposed in a manner that thermally insulates the thermally insulated region from the cryogenic agent to minimize heat extraction by the cryogenic agent from body tissue that is in contact with the thermally insulated region.