Reagents for directed biomarker signal amplification
AssigneeSirigen Group Limited
InventorsBrent S. Gaylord, Jean M. Wheeler, Glenn P. Bartholomew, Frank Peter Uckert, Janice W. Hong, William H. Huisman
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Abstract
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Claims13
A water soluble conjugated polymer having the structure of Formula:
- wherein:
- G1 and G2 are each independently selected from the group consisting of 1-9 having the structures:
- linker L1 is
- and is evenly or randomly distributed along the polymer main chain, wherein each R′ is independently a halogen, C1-C12 alkyl, or (C1-C12 alkyl)NH2;
- and n is an integer from 1 to about 10,000;
- and
- a and c define the mol % of each unit within the structure which each can be evenly or randomly repeated and where a is a mol % from about 75 to about 99% and c is mol % from about 1 to about 25%.
Dependencies are inferred from the claim text.