Back to results
US 8,329,158 B2Granted
Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsSyed F. A. Hossainy, Stephen D. Pacetti
Life of this patent
Estimating the term…
Abstract
Embodiments of the present invention provides medical devices comprising poly(hydroxyalkanoates) and agents.
Claims29
A medical article comprising a composition comprising a polymer represented by a formula:
- wherein the ratio of A:B is less than, greater than, or equal to one;
- A comprises
- B comprises a poly(ester amide)
- where R1 is selected from a group consisting of alkylenes, alkanoates, alkyl alkanoates, diesters, acylals, diacids, saturated fatty acids, glycerides, and combinations thereof;
- R2 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R3 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R4 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R6 is optional and is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R8 is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R11 through R14 are independently selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- L1 is a linkage connecting A to B;
- X is an agent;
- L2 is a linkage connecting X to said polymer;
- k is an integer;
- m is an integer from about 1 to about 40;
- and
- n, p, and z are integers not equal to zero, and
- wherein the agent comprises a component selected from a group consisting of phosphorylcholine, poly(N-vinyl pyrrolidone), poly(acrylamide methyl propane sulfonic acid), poly(styrene sulfonate), polysaccharides, poly(ester amides), non-thrombotics, antimicrobials, and combinations thereof.
25 more elements
A medical article comprising a blend or a mixture of a polymer and a bioactive agent, wherein the polymer is represented by a formula:
- wherein the ratio of A:B is less than, greater than, or equal to one;
- A comprises
- B comprises a poly(ester amide)
- where R1 is selected from a group consisting of alkylenes, alkanoates, alkyl alkanoates, diesters, acylals, diacids, saturated fatty acids, glycerides, and combinations thereof;
- R2 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R3 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R4 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R6 is optional and is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R8 is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R11 through R14 are independently selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- L1 is a linkage connecting A to B;
- X is a biobeneficial agent;
- L2 is a linkage connecting X to said polymer;
- k is an integer;
- m is an integer from about 1 to about 40;
- and
- n, p, and z are integers not equal to zero, and
- wherein the biobeneficial agent comprises a component selected from a group consisting of phosphorylcholine, poly(N-vinyl pyrrolidone), poly(acrylamide methyl propane sulfonic acid), poly(styrene sulfonate), polysaccharides, poly(ester amides), non-thrombotics, antimicrobials, and combinations thereof.
25 more elements
A stent comprising a coating, wherein the coating comprises a polymer represented by a formula:
- wherein the ratio of A:B is less than, greater than, or equal to one;
- A comprises
- B comprises a poly(ester amide)
- where R1 is selected from a group consisting of alkylenes, alkanoates, alkyl alkanoates, diesters, acylals, diacids, saturated fatty acids, glycerides, and combinations thereof;
- R2 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R3 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R4 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R6 is optional and is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R8 is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R11 through R14 are independently selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- L1 is a linkage connecting A to B;
- X is a biobeneficial agent;
- L2 is a linkage connecting X to said polymer;
- k is an integer;
- m is an integer from about 1 to about 40;
- and
- n, p, and z are integers not equal to zero, and
- wherein the biobeneficial agent comprises a component selected from a group consisting of phosphorylcholine, poly(N-vinyl pyrrolidone), poly(acrylamide methyl propane sulfonic acid), poly(styrene sulfonate), polysaccharides, poly(ester amides), non-thrombotics, antimicrobials, and combinations thereof.
25 more elements
A stent comprising a blend or mixture of (i) a polymer comprising a poly(hydroxyalkanoate) and (ii) a bioactive agent, wherein the polymer is represented by a formula:
- wherein the ratio of A:B is less than, greater than, or equal to one;
- A comprises
- B comprises a poly(ester amide)
- where R1 is selected from a group consisting of alkylenes, alkanoates, alkyl alkanoates, diesters, acylals, diacids, saturated fatty acids, glycerides, and combinations thereof;
- R2 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R3 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R4 is selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R6 is optional and is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R8 is selected from a group consisting of substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- R11 through R14 are independently selected from a group consisting of hydrogen;
- substituted, unsubstituted, hetero-, straight-chained, branched, cyclic, saturated and unsaturated aliphatic radicals;
- and substituted, unsubstituted, and hetero-aromatic radicals;
- L1 is a linkage connecting A to B;
- X is a biobeneficial agent;
- L2 is a linkage connecting X to said polymer;
- k is an integer;
- m is an integer from about 1 to about 40;
- and
- n, p, and z are integers not equal to zero, and
- wherein the biobeneficial agent comprises a component selected from a group consisting of phosphorylcholine, poly(N-vinyl pyrrolidone), poly(acrylamide methyl propane sulfonic acid), poly(styrene sulfonate), polysaccharides, poly(ester amides), non-thrombotics, antimicrobials, and combinations thereof.
25 more elements
Dependencies are inferred from the claim text.