Transcription infidelity, detection and uses thereof
AssigneeTransmedi SA
InventorBernard Bihain
Life of this patent
Estimating the term…
Abstract
The present invention relates to the identification of a novel mechanism of transcription infidelity in cells. The invention provides compositions and methods to detect the level of transcript ion infidelity in a sample, as well as the use thereof, e.g., for therapeutic, diagnostic, pharmacogenomic or drug design. As will be disclosed, the invention is particularly suited for detecting, monitoring or treating proliferative cell disorders, for the design and/or screening of drugs, for patient or disease profiling, prediction of disease severity and evaluation of drug efficacy.
Claims15
A method to diagnose the presence of a cancer in a subject, the method comprising the following steps:
- (a) detecting in vitro or ex vivo the presence or rate of transcription infidelity in a sample from said subject, wherein said transcription infidelity introduces sequence variations into an RNA primary transcript during transcription of DNA to RNA, and
- (b) diagnosing the presence of cancer in said subject, said presence or rate of transcription infidelity is an indication of the presence of a cancer in said subject.
Dependencies are inferred from the claim text.