Conversion of apoptotic proteins
AssigneeThe Burnham Institute
InventorsJohn C. Reed, Xiao-kun Zhang, Bin Guo, Bingzhen Lin, Siva Kumar Kolluri
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Abstract
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
Claims8
A method of inducing apoptosis in a cancer cell, comprising contacting said cell with a compound capable of inducing a conformational change in Bcl-2, so as to convert said Bcl-2 into a pro-apoptotic form, without cleaving said Bcl-2, wherein said compound is a peptide compound, and wherein said peptide compound comprises a Bcl-2 binding fragment of the human TR3 receptor of SEQ ID NO:
- 3 having Bcl-2 binding activity.
Dependencies are inferred from the claim text.