Imaging infection with compounds that bind to thymidine kinase
AssigneeThe Johns Hopkins University
InventorsMartin G. Pomper, Chetan Bettegowda, Catherine Foss, Shibin Zhou, Kenneth Kinzler, Bert Vogelstein
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Abstract
The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.
Claims21
A method for diagnosing a bacterial infection in a subject comprising:
- administering to the subject a compound suitable for imaging which binds to an endogenous bacterial thymidine kinase present in the infecting bacteria;
- and
- obtaining an image of the subject to determine the presence and location of the compound;
- wherein a localization of the compound is indicative that the subject has a bacterial infection wherein the compound is a radiolabeled nucleoside.
A method for imaging a bacterial infection in a subject comprising:
- administering to the subject a compound suitable for imaging which binds to an endogenous bacterial thymidine kinase present in the infecting bacteria;
- and
- obtaining an image of the subject;
- thereby obtaining an image of the bacterial infection in a subject wherein the compound is a radiolabeled nucleoside.
A method for imaging bacterial-based anticancer therapy comprising:
- administering to a subject a compound suitable for imaging which binds to an endogenous bacterial thymidine kinase present in a therapeutic bacteria;
- and
- imaging the subject to determine the presence and location of the compound;
- thereby imaging a bacterial-based anticancer therapy wherein the compound is a radiolabeled nucleoside.
Dependencies are inferred from the claim text.