Preparation of solvent-borne polymeric bioactive coatings
AssigneesToyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation, Regents of the University of Minnesota
InventorsPing Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Xiaodong Tong, Minjuan Zhang
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Abstract
Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantially free of surfactant is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material.
Claims23
A process for preparation of a protein-polymer composite material, comprising:
- providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent;
- mixing an aqueous solution containing bioactive proteins with the admixture, wherein the aqueous solution is substantially free of surfactant, to produce an emulsion
- mixing the emulsion with a crosslinker to produce a curable composition;
- and
- curing the curable composition, thereby producing the protein-polymer composite material.
A process for preparation of a protein-polymer composite material, comprising:
- providing an admixture of a hydroxyl-functionalized acrylate resin, a surfactant and a solvent, the solvent having a log P in the range of −0.5-2, inclusive;
- mixing an aqueous solution containing a bioactive protein with the admixture, wherein the aqueous solution is substantially free of surfactant, to produce an emulsion;
- mixing the emulsion with a polyisocyanate crosslinker to produce a curable composition;
- and
- curing the polymerizable composition, thereby producing the composite material.
A process for preparation of a protein-polymer composite material, comprising:
- providing an admixture of a polymer resin and a non-aqueous organic solvent;
- mixing an aqueous solution containing bioactive proteins with the admixture, wherein the aqueous solution is substantially free of surfactant, to produce a first component;
- providing a second component comprising a crosslinker;
- mixing the first component and the second component to produce a curable composition;
- and
- curing the curable composition, thereby producing the protein-polymer composite material.
A protein-polymer composite material, comprising:
- bioactive proteins dispersed in a two component solvent-borne polymer resin, the average particle size of bioactive protein particles in the protein-polymer composite material is in the range of 1 nm to 10 μm (average diameter), inclusive, with the proviso that the bioactive proteins are not ion-paired.
A curable protein-polymer composite material, comprising:
- bioactive proteins dispersed in a curable two component solvent-borne polymer resin, the average particle size of bioactive protein particles in the protein-polymer composite material is in the range of 1 nm to 10 μm (average diameter), inclusive, with the proviso that the bioactive proteins are not ion-paired.
Dependencies are inferred from the claim text.