Back to results
US 8,236,337 B2Granted
Anti-microbial orthodontic compositions and appliances and methods of production and use thereof
AssigneeSelenium, Ltd.
InventorsTed Reid, Julian Spallholz, Thirumal N. Devanathan, Thomas Mosley
Life of this patent
Estimating the term…
Abstract
The presently disclosed and claimed invention is directed to anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions comprising an effective amount of a selenium compound, kits containing same, and methods of producing and using said anti-microbial orthodontic apparatus and anti-microbial orthodontic compositions.
Claims60
An anti-microbial orthodontic apparatus, comprising:
- an orthodontic device;
- an anti-microbial coating applied to the orthodontic device, wherein the anti-microbial coating comprises an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl-acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl)propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), and wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface of the orthodontic device.
An anti-microbial orthodontic composition, comprising:
- an orthodontic composition;
- an anti-microbial composition disposed in the orthodontic composition, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl-acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl) propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), and wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface to which the orthodontic composition is applied.
A kit, comprising:
- an anti-microbial orthodontic composition comprising:
- at least one of an adhesive, a sealant and a cement;
- an anti-microbial composition disposed in the at least one of an adhesive, a sealant and a cement, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl-acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl)propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), and wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface to which the orthodontic composition is applied;
- and
- an activator.
2 more elements
A kit, comprising:
- an orthodontic device;
- and
- an anti-microbial orthodontic composition comprising:
- at least one of an adhesive, a sealant and a cement;
- an anti-microbial composition disposed in the at least one of an adhesive, a sealant and a cement, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl -acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl)propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), and wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface of the orthodontic device.
2 more elements
A method of producing an anti-microbial orthodontic apparatus, comprising the step of:
- applying an anti-microbial coating to an orthodontic device, wherein the anti-microbial coating comprises an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl-acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl) propionyloxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), and wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface of the orthodontic device.
A method of producing an anti-microbial orthodontic composition, comprising the step of:
- disposing an anti-microbial composition into an orthodontic composition to provide an anti-microbial orthodontic composition, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl-acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl)propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), and wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface to which the orthodontic composition is applied.
A method of binding an orthodontic device to a tooth, comprising the step of:
- binding an orthodontic device to a tooth with an effective amount of an anti-microbial orthodontic composition, whereby the anti-microbial orthodontic composition prevents the growth of microbes on at least one of the orthodontic device and the tooth, and wherein the ant-microbial orthodontic composition comprises at least one of an adhesive, a sealant and a cement having an anti-microbial composition disposed therein, the anti-microbial composition disposed in the at least one of an adhesive, a sealant and a cement comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl-acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl)propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), and wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface of at least one of the orthodontic device and the tooth.
A method of binding an anti-microbial device to a tooth, comprising the step of:
- binding an anti-microbial orthodontic apparatus to a tooth, the anti-microbial orthodontic apparatus comprising an orthodontic device having an anti-microbial coating applied thereto, whereby the anti-microbial coating prevents the growth of microbes on the orthodontic device, and wherein the anti-microbial coating comprises an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl-acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl)propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface of the orthodontic device.
A method of applying an antimicrobial coating to a tooth, comprising the step of:
- disposing an effective amount of the anti-microbial dental composition on at least a portion of the tooth, thereby preventing the growth of microbes on the tooth, wherein the anti-microbial dental composition comprises a sealant having an anti-microbial composition disposed therein, the anti-microbial composition comprising an effective amount of a selenium compound, wherein the selenium compound is selected from the group consisting of 3-[3-(2-{1-Methyl-2-[2-(2-methyl -acryloyloxy)-ethoxycarbonyl]-ethoxycarbonyl}-ethyldiselenyl)propionyl oxy]-butyric acid 2-(2-methyl-acryloyloxy)-ethyl ester (diSeAAEMA) and Di(cyclohexylmethyl-selenide), wherein the selenium compound allows for formation of the selenium anion Se— and free radical species and provides permanent attachment of the selenium anion Se— to a surface of the tooth.
Dependencies are inferred from the claim text.